Efficacy of Pentoxifylline

Currently, there is debate as to whether pentoxifylline has any efficacy in preventing the progression of PD (curvature, deformity, pain, length changes) in men who have newly discovered PD
The objective of the current study is to evaluate the efficacy of pentoxifylline on preventing or improving penile curvature, pain, length changes, or deformity when taken within 3 months of disease onset
To accomplish this objective, 40 men will be randomized into either pentoxifylline or placebo and followed until they are 6 months out from disease onset

Men wishing to participate will be randomly assigned to either placebo (sugar pill) or pentoxifylline until the participant is 6 months out from disease onset
In-office measurements will be obtained at baseline, 6 weeks after starting treatment, and once the patient is 6 months out from disease onset
Study questionnaires will be obtained either in person or electronically at baseline, 6 weeks, once 6 months out from disease onset, and 1 year after study initiation

A total of 40 men will be enrolled
Must have new onset PD (within 3 months of first noticing any aspect of PD: pain, curvature, nodularity, other deformity)
Ability to achieve an erection satisfactory for intercourse with or without PDE5 inhibitors (e.g. Viagra, Levitra, Cialis, Stendra)
No prior treatment of PD

Participants in the clinical study will have all study related costs paid for, including the cost of clinical evaluation, penile ultrasound, and treatment (placebo or pentoxifylline)
Transportation costs will also be reimbursed up to $500 per trip
Participants will also be given up to $600 for participation (if completing all visits and questionnaires)

The study is currently seeking funding and will begin once sufficient funding has been secured