Prednisone After Reversal

Currently, there is debate as to whether prednisone improves outcomes post vasectomy reversal
The objective of the current study is to determine whether prednisone, when used on a scheduled or as needed basis post-operatively, improves pregnancy outcomes or sperm concentration
To accomplish this objective, 100 men will be randomized into either control or 3 different protocols of prednisone administration and followed for 3 years to assess long-term outcomes

Men wishing to participate will be randomly assigned to either controls or one of three prednisone groups
Participants will mail-in sperm checks monthly for 1 year, followed by every 6 months for two additional years
Study questionnaires will be obtained periodically to assess for pregnancy or other fertility treatments

A total of 100 men will be enrolled
Must be undergoing a vasectomy reversal at the Male Fertility and Peyronie's Clinic
Several other inclusion / exclusion criteria apply (need to be actively attempting to achieve a pregnancy, partner 35 and younger, no contraceptives within 3 months, no testosterone use, no hypertension or diabetes, prior history of paternity)

Participants in the clinical study will receive all mail-in sperm kits at no cost
Participants will be given $150 by the conclusion of the study for mailing in specimen
Funding for the study is paid for by the Male Fertility and Peyronie's Clinic